Medical Physics Research - Medicine, Radiotherapy, Biomechanics, Medical Imaging

Medical Physics Research Today is a free monthly online journal that collates and summarizes the latest research about Medical Physics, including details on medicine, radiotherapy, biomechanics, medical imaging.


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A technique for stereotactic radiosurgery treatment planning with helical tomotherapy.

Soisson ET, Hoban PW, Kammeyer T, Kapatoes JM, Westerly DC, Basavatia A, Tomé WA

Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

The purpose of this study was to develop an efficient and effective planning technique for stereotactic radiosurgery using helical tomotherapy. Planning CTs and contours of 20 patients, previously treated in our clinic for brain metastases with linac-based radiosurgery using circular collimators, were used to develop a robust TomoTherapy planning technique. Plan calculation times as well as delivery times were recorded for all patients to allow for an efficiency evaluation. In addition, conformation and homogeneity indices were calculated as metrics to compare plan quality with that which is achieved with conventional radiosurgery delivery systems. A robust and efficient planning technique was identified to produce plans of radiosurgical quality using the TomoTherapy treatment planning system. Dose calculation did not exceed a few hours and resulting delivery times were less than 1 hour, which allows the process to fit into a single day radiosurgery workflow. Plan conformity compared favorably with published results for gamma knife radiosurgery. In addition, plan homogeneity was similar to linac-based approaches. The TomoTherapy planning software can be used to create plans of acceptable quality for stereotactic radiosurgery in a time that is appropriate for a radiosurgery workflow that requires that planning and delivery occur within 1 treatment day.

Published 8 February 2010 in Med Dosim.
Full-text of this article is available online (may require subscription).


Articles on Medical Physics published 8 February 2010:

Clinical performance of a transmission detector array for the permanent supervision of IMRT deliveries.   Radiother Oncol.

BACKGROUND AND PURPOSE: Clinical evaluation of a novel dosimetric accessory serving the permanent supervision of MLC function. MATERIALS AND METHODS: The DAVID system (PTW-Freiburg, Germany) is a transparent, multi-wire transmission ionization chamber, placed in the accessory holder of the treatment head. Since each of the 37 individual wires is positioned exactly below the associated leaf pair of the MLC, its signal records the opening of this leaf pair during patient treatment. RESULTS: The ... [Abstract] [Full-text]

Nanotopographical modification: A regulator of cellular function through focal adhesions.   Nanomedicine.

As materials technology and the field of biomedical engineering advances, the role of cellular mechanisms, in particular adhesive interactions with implantable devices, becomes more relevant in both research and clinical practice. A key tenet of medical device design revolves around the exquisite ability of biological systems to respond to topographic features or chemical stimuli, a process which has led to the development of next-generation biomaterials for a wide variety of clinical ... [Abstract] [Full-text]

So many definitions of heart failure: are they all universally valid? A critical appraisal.   Expert Rev Cardiovasc Ther, 8(2): 217-28.

Defining heart failure (HF) is a matter of finding the most appropriate words to formulate the definiens for HF that will be universally applicable in all specific circumstances pertaining to the nature of HF. Currently available definitions of HF contain ambiguities and notable deficiencies such that non-heart failure medical conditions can become mislabelled as heart failure. Principles of how best to formulate definitions have been employed to provide a guide on how to appraise published ... [Abstract] [Full-text]

Selenium and hormone interactions in female patients with hashimoto disease and healthy subjects.   Endocr Res, 35(1): 24-34.

Objective. To examine the correlation structure of parameters expressing selenium status, sex hormones secretion and thyroid function in a group of patients with Hashimoto disease and healthy female subjects. Method. Partial Least Square modeling was applied to parameters under study. Results. The correlations between relevant parameters were confirmed. Selenoenzyme glutathione peroxidase (GPX3) an progesterone played the most significant roles among factors contributing to thyroid stimulating ... [Abstract] [Full-text]

Three methods assessing red marrow dosimetry in lymphoma patients treated with radioimmunotherapy.   Cancer, 116: 1093-1100.

BACKGROUND:: Maximum injected activity in radioimmunotherapy (RIT) is limited by bone marrow toxicity. Many dosimetric approaches have been proposed, leading to high variability in the results and elusive absorbed dose-effect relations. This study presents the results of red marrow (RM) absorbed dose estimates performed with 3 methods. METHODS:: Five patients received 2 co-infusions of (90)Y-labeled (370 MBq/m2) and (111)In- labeled (120 MBq) epratuzumab (1.5 mg/kg) 1 week apart. RM-absorbed ... [Abstract] [Full-text]


Articles on Medical Physics published 5 February 2010:

Metabonomics in ulcerative colitis: diagnostics, biomarker identification, and insight into the pathophysiology.   J Proteome Res, 9(2): 954-62.

Nuclear magnetic resonance (NMR) spectroscopy and appropriate multivariate statistical analyses have been employed on mucosal colonic biopsies, colonocytes, lymphocytes, and urine from patients with ulcerative colitis (UC) and controls in order to explore the diagnostic possibilities, define new potential biomarkers, and generate a better understanding of the pathophysiology. Samples were collected from patients with active UC (n = 41), quiescent UC (n = 33), and from controls (n = 25) and ... [Abstract] [Full-text]

Dynamic Multileaf Collimator Tracking of Respiratory Target Motion Based On a Single Kilovoltage Imager During Arc Radiotherapy.   Int J Radiat Oncol Biol Phys.

PURPOSE: To demonstrate and characterize dynamic multileaf collimator (DMLC) tracking of respiratory moving targets that are spatially localized with a single kV X-ray imager during arc radiotherapy. METHODS AND MATERIALS: During delivery of an arc field (358 degrees gantry rotation, 72-sec duration, circular field shape), the three-dimensional (3D) position of a fiducial marker in a phantom was estimated in real time from fluoroscopic kV X-ray images acquired orthogonally to the treatment beam ... [Abstract] [Full-text]

Shotgun approach based comparative proteomic analysis of levo-tetrahydropalmatine-induced apoptosis in hepatocytes.   Toxicol Lett.

The analgesic agent levo-tetrahydropalmatine (l-THP) was reported to be associated with acute or chronic hepatitis in clinical practice. We found that l-THP can induce apoptosis in the hepatocytes of BALB/c mice and human normal liver L-02 (L-02) cells. Several key molecules, including caspase-3, Bcl-2, BAD and Bax, were modulated by l-THP treatment. A novel high-throughput proteomic approach based on 2D-nano-LC-MS/MS was applied to simultaneously evaluate the alterations of global protein ... [Abstract] [Full-text]


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Medical Physics Books

Radiation Oncology: A Physicist's-Eye View (Biological and Medical Physics, Biomedical Engineering)

Radiation Oncology: A Physicist's-Eye View (Biological and Medical Physics, Biomedical Engineering)