Medical Physics Research Today is a free monthly online journal that collates and summarizes the latest research about Medical Physics, including details on medicine, radiotherapy, biomechanics, medical imaging.

Clinical two-photon microendoscopy.

König K, Ehlers A, Riemann I, Schenkl S, Bückle R, Kaatz M

Fraunhofer Institute of Biomedical Technology (IBMT), St. Ingbert, Saarland, Germany. karsten.koenig@ibmt.fraunhofer.de

Two-photon medical imaging has found its way into dermatology as an excellent method for noninvasive skin cancer detection without need of contrast agents as well as for in situ drug screening of topically-applied cosmetical and pharmaceutical components. There is an increasing demand to apply the multiphoton technology also for deep-tissue skin imaging as well as for intracorporal imaging. We report on the first clinical use of multiphoton endoscopes, in particular of a miniaturized rigid two-photon GRIN lens endoscope. The microendoscope was attached to the multiphoton tomograph DermaInspect and employed to detect the extracellular matrix proteins collagen and elastin in the human dermis of volunteers and patients with ulcera by in vivo second harmonic generation and in vivo two-photon autofluorescence.

Published 30 April 2007 in Microsc Res Tech, 70(5): 398-402.
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